Alzheimer disease

Alzheimer Disease
Alzheimer disease
Alzheimer disease


Alzheimer disease is a degenerative disease of the brain that leads to dementia (mental deterioration). Nearly half of the senior housing clientele is made up of ALZHEIMER patients. From 5% to 15% of the over 65s are affected, and up to 50% of the over 85s die.  In 2007, the number of people affected was estimated at 100,000 in Quebec.


The disease is characterized by loss of memory, reduction of the duration of attention, disorientation, in the last stages of the disease, the inability to recognize easygoing people become in some years irritable moody, disoriented, sometimes violent, and end up having hallucinations.



The disease Is association with deficiency Acetylcholine and to change structurally the brain, especially in regions governing cognition and memory. The disease seems to have a hereditary component in some cases.
Researchers study a protein called (TAU) in the role, similar would link (rails) that are microtubules. In the brain individuals achieved Alzheimer disease, TAU stops stabilize microtubules and attaches to other molecules thus forming of entanglement neurofibrillary. This degeneration installed during a period of a few years during which the close of the person reached the see slowly (decrease) the process is long and painful. It is hoped that research, especially stem cell research, will converge one day and result in the discovery of a treatment. One of the current areas of research is the injection of microglia from stem cells in the subject bone marrow and genetically engineered to increase their efficiency in the destruction of   Beta-amyloid peptide plaque.


The recent development of a (plaque) biomarker may also help to diagnose the disease more quickly. While waiting for the results of this research, one must be content with administrating drugs that mitigate the symptoms by inhibition of the degradation of Ach. Such as Donepezil.  We can also try to prevent the disease, for example using Antioxidants, which could neutralize free radicals whose presence of Beta-amyloid peptides is responsible.


Location: NE 20th Ave, Iuka, KS 67066, États-Unis

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